A Comprehensive Analysis of the Relationship Between Polycystic Ovary Syndrome and Anxiety
DOI:
https://doi.org/10.56294/hl2025617Keywords:
Polycystic ovarian syndrome, Anxiety Disorders, Hormonal Imbalance, Metabolic Dysfunction, Inflammation and Mental HealthAbstract
Background: Polycystic Ovary Syndrome (PCOS) is a reproductive, metabolic, and psychiatric endocrine disorder. The increasing evidence points toward the firm relationship between PCOS and anxiety but does not identify the underlying relationships.
Aim: To investigate the relationship between PCOS and anxiety, evaluating potential causative factors including hormonal deregulation, metabolic imbalance, and markers of inflammation.
Methods: The research involved 250 women participants were recruited, 150 with PCOS (experimental group) and 100 controls. Anxiety was measured by a validated questionnaire for anxiety. Hormonal and metabolic variables, such as insulin resistance (HOMA-IR), testosterone, BMI, and C-reactive protein (CRP), were measured and correlated with anxiety scores. Statistical tests were utilized to establish significant differences and correlations.
Results: The evidence favours hormonal dysregulation, metabolic derangement, and systemic inflammation as the etiopathogenic factors in anxiety in PCOS patients. Hyperandrogenism and insulin resistance are associated with neuro-chemical alterations in mood control, while systemic inflammation is associated with increased psychological distress. These physiological changes could be the intrinsic factors for increased incidence of anxiety in PCOS.
Conclusion: The research identifies a high level of correlation between PCOS and anxiety, with insulin resistance, elevated testosterone, BMI, and inflammation being significant contributory factors. Intervention in these variables is helpful in improving mental health outcomes among PCOS patients. Longitudinal trends and possible therapeutic options for decreasing anxiety in this group should be the focus of future studies.
References
1. Almeshari WK, Alsubaie AK, Alanazi RI, Almalki YA, Masud N, Mahmoud SH. Depressive and anxiety symptom assessment in adults with polycystic ovarian syndrome. Depression research and treatment. 2021;2021(1):6652133.https://doi.org/10.1155/2021/6652133
2. Yin X, Ji Y, Chan CL, Chan CH. The mental health of women with polycystic ovary syndrome: a systematic review and meta-analysis. Archives of women's mental health. 2021 Feb;24:11-27.https://doi.org/10.1007/s00737-020-01043-x
3. Dybciak P, Humeniuk E, Raczkiewicz D, Krakowiak J, Wdowiak A, Bojar I. Anxiety and depression in women with polycystic ovary syndrome. Medicina. 2022 Jul 16;58(7):942.https://doi.org/10.3390/medicina58070942
4. Wang Z, Dong H, Wang Q, Zhang L, Wu X, Zhou Z, Yang L, Huang D. Effects of electroacupuncture on anxiety and depression in unmarried patients with polycystic ovarian syndrome: secondary analysis of a pilot randomised controlled trial. Acupuncture in Medicine. 2019 Feb;37(1):40-6.https://doi.org/10.1136/acupmed-2017-011615
5. Wang Y, Ni Z, Li K. The prevalence of anxiety and depression of different severity in women with polycystic ovary syndrome: a meta-analysis. Gynecological Endocrinology. 2021 Dec 2;37(12):1072-8. https://doi.org/10.1080/09513590.2021.1942452
6. Lin H, Liu M, Zhong D, Ng EH, Liu J, Li J, Shi Y, Zhang C, Wen X, Mai Z, Ou M. The prevalence and factors associated with anxiety-like and depression-like behaviors in women with polycystic ovary syndrome. Frontiers in psychiatry. 2021 Oct 20;12:709674.https://doi.org/10.3389/fpsyt.2021.709674
7. Saei Ghare Naz M, Ramezani Tehrani F, Behroozi Lak T, Mohammadzadeh F, Nasiri M, Kholosi Badr F, Ozgoli G. Quality of life and emotional states of depression, anxiety and stress in adolescents with polycystic ovary syndrome: A cross-sectional research . Psychology Research and Behavior Management. 2020 Feb 28:203-9.https://doi.org/10.2147/PRBM.S241192
8. Mehrabadi S, Sadatmahalleh SJ, Kazemnejad A, Moini A. Association of acne, hirsutism, androgen, anxiety, and depression on cognitive performance in polycystic ovary syndrome: A cross-sectional research . International Journal of Reproductive BioMedicine. 2020 Dec 21;18(12):1049.https://doi.org/10.18502/ijrm.v18i12.8026
9. Alkoudsi KT, Basheti IA. Prevalence of anxiety and depression among women with Polycystic Ovary Syndrome living in war versus non-war zone countries: A randomized controlled trial assessing a pharmacist intervention. Research in Social and Administrative Pharmacy. 2020 Can 1;16(5):689-98.https://doi.org/10.1016/j.sapharm.2019.08.027
10. Asdaq SM, Yasmin F. Risk of psychological burden in polycystic ovary syndrome: A case control research in Riyadh, Saudi Arabia. Journal of affective disorders. 2020 Sep 1;274:205-9.https://doi.org/10.1016/j.jad.2020.05.086
11. Koric A, Singh B, VanDerslice JA, Stanford JB, Rogers CR, Egan DT, Agyemang DO, Schliep K. Polycystic ovary syndrome and postpartum depression symptoms: a population-based cohort research. American journal of obstetrics and gynecology. 2021 Jun 1;224(6):591-e1.https://doi.org/10.1016/j.ajog.2020.12.1215
12. Besenek M, Gurlek B. Hyperandrogenism in polycystic ovary syndrome affects psychological well‐being of adolescents. Journal of Obstetrics and Gynaecology Research. 2021 Jan;47(1):137-46.https://doi.org/10.1111/jog.14444
13. Cantelmi T, Lambiase E, Unfer VR, Gambioli R, Unfer V. Inositol treatment for psychological symptoms in Polycystic Ovary Syndrome women. European Review for Medical & Pharmacological Sciences. 2021 Mar 1;25(5).
14. Mohammadi M, Fatemi I, Taghipour Z, Azin M, Kaeidi A, Hakimizadeh E, Taghizadeh R, Hassanipour M. Polycystic ovary syndrome can lead to neurocognitive changes in female rats treated with letrozole. Arch Neurosci. 2021 Jan 1;8(2):e112023.doi: 10.5812/ans.112023.
15. Urban W, Nizioł A, Pytlewski A, Zaborowska Ł, Dadański E, Rutkowski K, Klasa K, Kacalska-Janssen O, Jach R, Mielimąka M. Polycystic ovary syndrome: personality and temperamental characteristics. Journal of Obstetrics and Gynaecology Canada. 2022 Jul 1;44(7):813-8.https://doi.org/10.1016/j.jogc.2022.03.011
16. Çoban ÖG, Tulacı ÖD, Adanır AS, Önder A. Psychiatric disorders, self-esteem, and quality of life in adolescents with polycystic ovary syndrome. Journal of pediatric and adolescent gynecology. 2019 Dec 1;32(6):600-4.https://doi.org/10.1016/j.jpag.2019.07.008
17. Biresaw H, Mulugeta H, Endalamaw A, Yesuf NN, Alemu Y. Patient satisfaction towards health care services provided in Ethiopian health institutions: a systematic review and meta-analysis. Health services insights. 2021 Aug;14:11786329211040689. https://doi.org/10.1177/11786329211040689
18. Cullen C, Kappelmann N, Umer M, Abdolizadeh A, Husain MO, Bonato S, Sharma G, Xue S, Ortiz A, Kloiber SM, Mulsant BH. Efficacy and acceptability of pharmacotherapy for comorbid anxiety symptoms in bipolar disorder: a systematic review and meta‐analysis. Bipolar disorders. 2021 Dec;23(8):754-66. https://doi.org/10.1111/bdi.13125
19. Osborn TL, Campbell S, Ndetei D, Weisz J. Netresearch analysis reveals central symptoms of adolescent depression and anxiety in Sub-Saharan Africa.
20. Vladimirovna SV, Anvarovna SL, Vladimirovna ME, Khidirovna LZ. Menstrual cycle disturbances in the reproductive period. Central Asian Journal of Medical and Natural Science. 2023;4(2):389-97.
21. Shahid S, Shahid A, Mahfooz I. Social isolation, illness anxiety, and quality of life in Corona survivors. Pakistan Journal of Psychological Research. 2021;36(4):515-28.https://doi.org/10.33824/PJPR.2021.36.4.28
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Copyright (c) 2025 Nidhi, Prashant Modi, Shivam Khurana, Sukhman Ghumman, Mansi Mishra, Bathala Balaji (Author)
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