Obesity-Related Breathing Disorders: Diagnosis and Treatment of Hypoventilation Syndrome

Authors

DOI:

https://doi.org/10.56294/hl2025612

Keywords:

Obesity, breathing disorders, hypoventilation, positive airway pressure treatment

Abstract

Introduction:Obesity-related respiratory problems,such hypoventilation syndrome, are on the rise and have depressing property on one's health. The characteristic of hypoventilation syndrome are shallow breathing and low blood oxygen levels, which consequence in symptoms similar to fatigue, headache, and cognitive defeat.
Methods:The analysis of this situation necessitates a mixture of clinical assessment, pulmonary function testing, and arterial blood gas capacity.Treatment options comprise weight defeat, positive airway pressure (PAP) treatment, and severe cases, tracheostomy or ventilator maintain. 
Results:Hypoventilation condition can enhance quality of life (QoL) and decrease the possibility of potentially fatal difficulty like heart failure and pulmonary hypertension (PH) with early diagnosis and treatment. 
Conclusion:The research, we recognize the disease's diagnostic individuality and inspect the path physiology, morbidity, and mortality that are connected.The research covers the frequent treatment alternative obtainable nowadays as final point.

References

1. Masa JF, Pépin JL, Borel JC, Mokhlesi B, Murphy PB, Sánchez-Quiroga MÁ. Obesity hypoventilation syndrome.EuropeanRespiratoryReview.2019Mar31;28(151).https://doi.org/10.1183/16000617.0097-2018

2. Togioka BM, McConville SS, Penchoen-Lind RM, Schenning KJ. Diagnosis and management of obesity hypoventilation syndrome during labor. Case Reports in Anesthesiology. 2021;2021(1):8096212. https://doi.org/10.1155/2021/8096212

3. Shah NM, Shrimanker S, Kaltsakas G. Defining obesity hypoventilation syndrome. Breathe. 2021 Sep 1;17(3).https://doi.org/10.1183/16000617.0097-2018

4. Athayde RA, Oliveira Filho JR, Lorenzi Filho G, Genta PR. Obesity hypoventilation syndrome: a current review. Jornal Brasileiro de Pneumologia. 2018 Nov;44:510-8.https://doi.org/10.1590/S1806-37562017000000332

5. Zheng Y, Phillips CL, Sivam S, Wong K, Grunstein RR, Piper AJ, Yee BJ. Cardiovascular disease in obesity hypoventilation syndrome–A review of potential mechanisms and effects of therapy. Sleep Medicine Reviews. 2021 Dec 1;60:101530.https://doi.org/10.1016/j.smrv.2021.101530

6. Sivam S, Yee B, Wong K, Wang D, Grunstein R, Piper A. Obesity hypoventilation syndrome: early detection of nocturnal-only hypercapnia in an obese population. Journal of Clinical Sleep Medicine. 2018 Sep 15;14(9):1477-84.https://doi.org/10.5664/jcsm.7318

7. Coelho DB. Obesity Hypoventilation Syndrome. InTeaching Pearls in Noninvasive Mechanical Ventilation: Key Practical Insights 2022 Feb 1 (pp. 457-463). Cham: Springer International Publishing.https://doi.org/10.1007/978-3-030-71298-3_50

8. Utpat K, Desai U, Joshi JM, Bharmal RN. Obesity Hypoventilation Syndrome: New Insights in Diagnosis and Management. Management. 2020;15(1):9-14.

9. Herkenrath SD, Treml M, Hagmeyer L, Matthes S, Randerath WJ. Severity stages of obesity-related breathing disorders–a cross-sectional cohort study. Sleep Medicine. 2022 Feb 1;90:9-16.https://doi.org/10.1016/j.sleep.2021.12.015

10. Goyal A, Pakhare A, Tiwari IR, Khurana A, Chaudhary P. Diagnosing obstructive sleep apnea patients with isolated nocturnal hypoventilation and defining obesity hypoventilation syndrome using new European Respiratory Society classification criteria: an Indian perspective. Sleep Medicine. 2020 Feb 1;66:85-91.https://doi.org/10.1016/j.sleep.2019.08.009

11. Raveendran R, Wong J, Chung F. Morbid obesity, sleep apnea, obesity hypoventilation syndrome: Are we sleepwalking into disaster?. Perioperative Care and Operating Room Management. 2017 Dec 1;9:24-32.https://doi.org/10.1016/j.pcorm.2017.11.010

12. Warricker F, Islam Z, Shah BN. Lesson of the month 1: obesity hypoventilation (Pickwickian) syndrome: a reversible cause of severe pulmonary hypertension. Clinical Medicine. 2017 Dec 1;17(6):578-81.https://doi.org/10.7861/clinmedicine.17-6-578

13. Sunwoo BY. Obesity hypoventilation: Pathophysiology, diagnosis, and treatment. Current Pulmonology Reports. 2019 Jun 15;8:31-9.https://doi.org/10.1007/s13665-019-0223-x

14. Masa JF, Benítez ID, Javaheri S, Mogollon MV, Sánchez-Quiroga MÁ, de Terreros FJ, Corral J, Gallego R, Romero A, Caballero-Eraso C, Ordax-Carbajo E. Risk factors associated with pulmonary hypertension in obesity hypoventilation syndrome. Journal of Clinical Sleep Medicine. 2022 Apr 1;18(4):983-92.https://doi.org/10.5664/jcsm.9760

15. Gavala AC, Myrianthefs PM. Non Invasive Ventilation: Nocturnal Hypoventilation and Sleep Breathing Disorders. InTeaching Pearls in Noninvasive Mechanical Ventilation: Key Practical Insights 2022 Feb 1 (pp. 379-393). Cham: Springer International Publishing.https://doi.org/10.1007/978-3-030-71298-3_43

16. Chada A, Zahiruddin F, Collop N. Obesity Hypoventilation Syndrome. Complex Sleep Breathing Disorders: A Clinical Casebook of Challenging Patients. 2021:127-36.https://doi.org/10.1007/978-3-030-57942-5_11

17. Tran K, Wang L, Gharaibeh SD, Kempke N, Rao Kashyap S, Cetin D, Aboussouan LS, Mehra R. Elucidating predictors of obesity hypoventilation syndrome in a large bariatric surgery cohort. Annals of the American Thoracic Society. 2020 Oct;17(10):1279-88.https://doi.org/10.1513/AnnalsATS.202002-135OC

18. Bhattacharjee R, Khalyfa A, Khalyfa AA, Mokhlesi B, Kheirandish-Gozal L, Almendros I, Peris E, Malhotra A, Gozal D. Exosomal cargo properties, endothelial function and treatment of obesity hypoventilation syndrome: a proof of concept study. Journal of Clinical Sleep Medicine. 2018 May 15;14(5):797-807.https://doi.org/10.5664/jcsm.7110

19. Khalyfa A, Masa JF, Qiao Z, González M, Marti S, Khalyfa AA, Kheirandish-Gozal L, Gozal D. Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties: Effect of long-term adherent CPAP treatment. Biochimica et Biophysica Acta (BBA)-Molecular basis of Disease. 2022 Oct 1;1868(10):166479.https://doi.org/10.1016/j.bbadis.2022.166479

20. Murphy PB, Patout M, Arbane G, Mandal S, Kaltsakas G, Polkey MI, Elliott M, Muir JF, Douiri A, Parkin D, Janssens JP. Cost-effectiveness of outpatient versus inpatient non-invasive ventilation setup in obesity hypoventilation syndrome: the OPIP trial. Thorax. 2023 Jan 1;78(1):24-31.https://doi.org/10.1136/thorax-2021-218497

Downloads

Published

2025-05-20

How to Cite

1.
Mishra P, Gupta S, Devmurari P, Raj N, Priya Natarajan N, Kumar A. Obesity-Related Breathing Disorders: Diagnosis and Treatment of Hypoventilation Syndrome. Health Leadership and Quality of Life [Internet]. 2025 May 20 [cited 2025 Jun. 24];4:612. Available from: https://hl.ageditor.ar/index.php/hl/article/view/612