Oral contraceptive use and breast cancer risk: A systematic review
DOI:
https://doi.org/10.56294/hl2024.330Keywords:
breast neoplasms, oral contraceptives, levonorgestrelAbstract
Introduction: Breast cancer is an oncological disease associated with the transformation of mammary cells influenced by hormones. It was necessary to review the relationship between the use of oral contraceptives and the risk of developing the disease. Objectives: To analyze the relationship between oral contraceptives and the risk of breast cancer and to identify the hormonal components involved. Methodology: Articles from 2010 to August 2024 were reviewed in Scielo and Google Scholar, including systematic and original studies in Spanish, English, and Portuguese, excluding irrelevant articles. Results and Discussion: Some studies suggested a relationship between oral contraceptives and breast cancer, especially with triphasic formulations, levonorgestrel, and in women with BRCA-1 and BRCA-2 mutations. Conclusions: The use of oral contraceptives increases the risk of breast cancer, but this risk decreases if they are discontinued at least 5 years after initiation.
References
Alsammarraie, A., Mubarak, A., Alnuaimi, A., & Kamal, A. (Diciembre de 2020). Association of Oral Contraceptives use with Breast Cancer and Hormone Receptor Status in Iraqi Women. Open Access Macedonian Journal of Medical Sciences, 8(B), 1244-1250. doi:https://doi.org/10.3889/oamjms.2020.5030
Barriga, P., Vanhauwaert, P., & Porcile, A. (Febrero de 2019). Hormonal contraception and risk of breast cancer: a critical look. Gynecological Endocrinology, 35(6), 460-462. doi:https://doi.org/10.1080/09513590.2019.1576610
Beaber, E., Buist, D., Barlow, W., Malone, K., Reed, S., & Li, C. (Agosto de 2014). Recent Oral Contraceptive Use by Formulation and Breast Cancer Risk among Women 20 to 49 Years of Age. Cancer Research, 74(15), 4078–4089. doi:https://doi.org/10.1158/0008-5472.CAN-13-3400
Boeno, X., & do Amaral Júnior, O. (Abril de 2024). O USO DE CONTRACEPTIVOS ORAIS E SUA RELAÇÃO COM O CÂNCER DE MAMA: UMA REVISÃO DE LITERATURA. Revista de Ciências da Saúde, 3(1), 34-52. Obtenido de https://revistas.uceff.edu.br/reviva/article/view/468/533
Calderón, A. (Marzo de 2017). Anticonceptivos Oral. Revista Médica Sinergia, 2(3), 16-21. Obtenido de https://revistamedicasinergia.com/index.php/rms/article/view/69
Cardoso, M. D. (Enero de 2020). Associação entre câncer de mama e uso de contraceptivos orais de mulheres em idade fértil. Universidade Federal do Ceará. Obtenido de https://repositorio.ufc.br/handle/riufc/50022
Creinin, M., & Khan, S. (Abril de 2024). Contemporary understanding of breast cancer risk with combined oral contraceptives. Contemporary OB/GYN Journal, 69(2). Obtenido de https://www.contemporaryobgyn.net/view/contemporary-understanding-of-breast-cancer-risk-with-combined-oral-contraceptives
De Lemos, L. L., Carvalho de Souza, M., Pena, D., Ribeiro Fernandes Almeida, P., Godman, B., Verguet, S., . . . Leal Cherchiglia, M. (Octubre de 2019). Stage at diagnosis and stage-specific survival of breast cancer in Latin America and the Caribbean: A systematic review and meta-analysis. PLOS ONE, 14(10). doi:https://doi.org/10.1371/journal.pone.0224012
Dilma’aarij, D., Rahardjo, S., & Pamungkasari, E. (Marzo de 2021). Meta-Analysis the Effect of Oral and Injection Contraceptives on Breast Cancer. Journal of Maternal and Child Health, 6(2), 238-249. doi:https://doi.org/10.26911/the-jmch.2021.06.02.11
Elebro, K., Butt, S., Dorkhan, M., Jernström, H., & Borgquist, S. (Octubre de 2013). Abstract A126: Oral contraceptives and late first childbirth increase the risk of androgen receptor-negative breast cancer: The Malmö Diet and Cancer cohort. Molecular Cancer Research, 11(10). doi:https://doi.org/10.1158/1557-3125.ADVBC-A126
Franceschini, G., Di Leone, A., D'Archi, S., & Masetti, R. (Marzo de 2020). Oral contraceptives and breast cancer risk: An overestimated risk? Critical reviews in oncology/hematology, 147. doi:10.1016/j.critrevonc.2020.102876
García, A., Zaporta, J. A., Quishpe, P., & Zaporta, A. (Octubre de 2023). Revisión bibliográfica sobre cáncer de mama en adultos mayores. Recimundo, 7(3), 206-216. doi:https://doi.org/10.26820/recimundo/7.(3).sep.2023.206-216
Ghimire, S., Shrestha, N., & Baral, B. (Febrero de 2015). Oral contraceptives as a risk factor for developing breast cancer in breast cancer (BRCA) gene carrier female in-the 30–60 years age group: a meta analysis. International Journal of Medical Research & Health Sciences, 4(1), 135-143. doi:10.5958/2319-5886.2015.00022.3
Golshani, A. G. (2021). The Relationship Between Oral Contraceptives and Breast Cancer Risk. California State University San Marcos. Obtenido de https://scholarworks.calstate.edu/concern/theses/v692tc172?locale=fr
González, M., Polanco, L., Medina, X., & Abifadel, C. (Junio de 2014). Systematic Review on: Breast Cancer and its Relationship with Prolonged Use of Combined Oral Contraceptives. Más Vita, 6(2), 18-28. doi:https://doi.org/10.47606/ACVEN/MV0234
Hunter, D. (Diciembre de 2017). Oral Contraceptives and the Small Increased Risk of Breast. The New England Journal of Medicine, 377(23), 2276-2277. doi:10.1056/NEJMe1709636
Hunter, D., Colditz, G., Hankinson, S., Malspeis, S., Spiegelman, D., Chen, W., . . . Willett, W. (Octubre de 2010). Oral Contraceptive Use and Breast Cancer: A Prospective Study of Young Women. Cancer Epidemiology, Biomarkers & Prevention, 19(10), 2496–2502. doi:https://doi.org/10.1158/1055-9965.EPI-10-0747
Ichida, M., Kataoka, A., Tsushima, R., & Taguchi, T. (Mayo de 2015). No Increase in Breast Cancer Risk in Japanese Women Taking Oral Contraceptives: a Case-Control Study Investigating Reproductive, Menstrual and Familial Risk Factors for Breast Cancer. Asian Pacific Journal of Cancer Prevention, 16(9), 3685-3690. doi:https://doi.org/10.7314/APJCP.2015.16.9.3685
Iurova, M., Mezhevitinova, E., Yakushevskaya, O., Rodionov, V., & Prilepskaya, V. (Agosto de 2023). The effect of hormonal contraception on the risk of breast cancer: A review. Journal of Modern Oncology, 25(2), 199-207. doi:https://doi.org/10.26442/18151434.2023.2.202287
Kanadys, W., Barańska, A. B., Malm, M., Błaszczuk, A., Polz-Dacewicz, M., Janiszewska, M., & Jędrych, M. (Abril de 2021). Use of Oral Contraceptives as a Potential Risk Factor for Breast Cancer: A Systematic Review and Meta-Analysis of Case-Control Studies Up to 2010. International Journal of Environmental Research and Public Health, 18(9). doi:https://doi.org/10.3390/ijerph18094638
Karim, S., Wijdan, B., Neamatullah, S., & Bakr, B. (Mayo de 2015). Oral Contraceptives, Abortion and Breast Cancer Risk: a Case. Asian Pacific Journal of Cancer Prevention,, 16(9), 3957-3960. doi:http://dx.doi.org/10.7314/APJCP.2015.16.9.3957
Li-Wei, J., Chun-Xia, J., Su-Lian, Z., & Wei-Cheng, P. X.-P. (Septiembre de 2019). Effect of age at first use of oral contraceptives on breast cancer risk. Medicine, 98(36). doi:10.1097/MD.0000000000015719
Lorona, N., Cook, L., Tang, M.-T., Hill, D., Wiggins, C., & Li, C. (Abril de 2019). Recent Use of Oral Contraceptives and Risk of Luminal B, Triple-Negative, and HER2-Overexpressing Breast Cancer. Discover Oncology, 10, 71-76. doi:https://doi.org/10.1007/s12672-019-00362-5
Lovett, J., Chima, M., Wexler, J., Arslanian, K., Friedman, A., Yousif, C., & Strassmann, B. (Febrero de 2017). Oral contraceptives cause evolutionarily novel increases in hormone exposure: A risk factor for breast cancer. Evolution, Medicine, and Public Health, 2017(1), 97–108. doi: https://doi.org/10.1093/emph/eox009
Merki-Feld, G., Seeger, H., & Mueck, A. (Abril de 2012). Proliferative Effects of Estradiol- or Ethinylestradiol-Progestogen Combinations on Human Breast Cancer Cells in an Intermitted and a Long-term Regimen. Hormone and Metabolic Research, 44(6), 415- 421. doi:10.1055/s-0032-1308999
Mørch, L., Skovlund, C., Hannaford, P., Iversen, L., Fielding, S., & Lidegaard, Ø. (Diciembre de 2017). Contemporary Hormonal Contraception and the Risk of Breast Cancer. The New England Journal of Medicine, 377(23), 2228-2239. doi:10.1056/NEJMoa1700732
OMS. (Marzo de 2024). Cáncer de mama. Organización Mundial de la Salud. Obtenido de https://www.who.int/es/news-room/fact-sheets/detail/breast-cancer#:~:text=En%202022%2C%20en%20todo%20el,mayores%20entre%20las%20mujeres%20adultas.
Osorio, N., Bello, C., & Vega, L. (2020). Factores de riesgo asociados al cáncer de mama. Revista Cubana de Medicina General Integral, 36(2), 1-13. Obtenido de https://revmgi.sld.cu/index.php/mgi/article/view/1147/333
Peng, H., Qi, X., & Wang, Q. (Febrero de 2022). Long term use of oral contraceptives comprising synthetic estrogens. Clinical and Experimental Obstetrics & Gynecology, 49(1). doi:https://doi.org/10.31083/j.ceog4901009
Roy, A., Sarkar, B., & Bandyopadhyay, A. (Mayo de 2018). Oral Contraceptives and Breast Cancer Risk: A Study among the Bengalee Females of West Bengal, India. Significances of Bioengineering & Biosciences, 1(4). doi:10.31031/SBB.2018.01.000517
Ruaro, I., Goldmeir, R., & Marcio, T. (2023). CONTRACEPTIVOS ORAIS E CÂNCER DE MAMA: SUA RELAÇÃO COM A CLASSIFICAÇÃO MOLECULAR. Revista foco, 16(3). doi:10.54751/revistafoco.v16n3-098
Schrijver, L., Olsson, H., Phillips, K.-A., Terry, M., Goldgar, D., Kast, K., . . . Barrowdale, D. (Junio de 2018). Oral Contraceptive Use and Breast Cancer Risk: Retrospective and Prospective Analyses From a BRCA1 and BRCA2 Mutation Carrier Cohort Study. JNCI Cancer Spectrum, 2(2). doi:https://doi.org/10.1093/jncics/pky023
Trabert, B., Sherman, M., Kannan, N., & Stanczyk, F. (Abril de 2020). Progesterone and Breast Cancer. Endocrine Reviews, 41(2), 320–344. doi:https://doi.org/10.1210/endrev/bnz001
Utami, D., Murti, B., & Budihastuti, U. (2022). Oral and Injection Hormonal Contraceptives Uptake and Their Risk to Breast Cancer: A Meta-Analysis. Journal of Maternal and Child Health, 7(3), 346-358. doi:https://doi.org/10.26911/thejmch.2022.07.03.11
Work, M., John, E., Hopper, J. A., & Terry, M. (Noviembre de 2012). Abstract B98: Parity, breastfeeding and oral contraceptive use and risk of estrogen- and progesterone-negative breast cancer in the Breast Cancer Family Registry. Cancer Prevention Research, 5(11). doi:https://doi.org/10.1158/1940-6207.PREV-12-B98.
Published
Issue
Section
License
Copyright (c) 2024 Karen Valera, Camila S. Aguirre, Anthony V. Cornejo, Justhyn Loor, Kendry E. Cedeño, Eugenio R. Borroto (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
