Impact of Oral Contraceptives on Periodontal Health: Influence of Steroid Hormones
DOI:
https://doi.org/10.56294/hl2023263Keywords:
Periodontal disease, gingivitis, oral microbiome, oral contraceptives, steroid hormonesAbstract
Introduction: The oral cavity constitutes a dynamic niche susceptible to environmental and physiological changes. Alterations in its microbiome can lead to pathologies such as caries and periodontal disease, the latter being one of the main causes of tooth loss worldwide. Candida albicans has been identified as the most prevalent fungus in the oral microbiota, although detections of non-albicans species have increased in the last decade. In addition, steroid hormones such as estrogens and progesterone, present in oral contraceptives, have been shown to modulate the periodontal inflammatory response, exacerbating conditions such as gingivitis and favoring the progression of periodontal disease.
Development: This work explored the impact of oral contraceptives and steroid hormones on bacterial plaque-induced gingivitis and periodontitis progression. The most recent classifications of periodontal disease, which group pathologies according to stages and grades, were addressed, allowing a better assessment of hormonal factors in their evolution. The findings supported the relationship between oral contraceptive use and increased susceptibility to gingival inflammation, especially in advanced clinical conditions.
Conclusions: Steroid hormones, present in contraceptives, played an important role in modulating the oral microbiome and periodontal inflammation. Although no direct relationship was found in mild cases, in advanced stages of periodontal disease the hormonal impact was significant. These results highlight the need to monitor hormonal factors in dental treatment and to promote personalized preventive strategies.
References
Ademe M, Girma F. Candida auris: From multidrug resistance to pan-resistant strains. Infect Drug Resist. 2020;13:1287–94.
Avila M, Ojcius DM, Yilmaz O. The oral microbiota: living with a permanent guest. DNA Cell Biol. 2009;28(8):405–11.
Benito B, Aranda S, López F, de la Rosa E, Rosas R, Sánchez L. Oral Candida isolates and fluconazole susceptibility patterns in older Mexican women. Arch Gerontol Geriatr. 2016;65:204–10.
Borgo P, Rodrigues V, Feitosa A, Xavier K, Avila-Campos M. Association between periodontal condition and subgingival microbiota in women during pregnancy: a longitudinal study. J Appl Oral Sci. 2014;22(6):528–33.
Brusca M, Verdugo F, Amighini C, Albaina O, Moragues M. Anabolic steroids affect human periodontal health and microbiota. Clin Oral Investig. 2014;18(6):1579–86.
Brusca M, Rosa A, Olatz A, Moragues M, Verdugo F, Pontón J. The impact of oral contraceptives on women's periodontal health and the subgingival occurrence of aggressive periodontopathogens and Candida species. J Periodontol. 2010;81(7):1010–8.
Bulacio L, Paz M, Ramadan S, et al. Oral infections caused by yeasts in patients with head and neck cancer undergoing radiotherapy: Identification of the yeasts and evaluation of their antifungal susceptibility. J Mycol Med. 2012;22(4):348–53.
Carrillo de Albornoz A, Figuero E, Herrera D, Bascones A. Gingival changes during pregnancy: I. Influence of hormonal variations on clinical and immunological parameters. J Clin Periodontol. 2010;37(3):220–9.
Corgel J. Dental management of the female patient. J Clin Periodontol 2000. 2013;61:219–31.
Cuya-García R, Chávez-Raymi A, Flores-Culqui S, Párraga-Navarro M, Quinto-Benalcázar R, Tafur-Vásquez O. Enfermedad periodontal asociada al embarazo. Rev Cient Odontol (Lima). 2019;7(1):132–9.
De La Torre J, Quindos G, Marcos-Arias C, Marichalar-Mendia X, Gainza ML, Eraso E, et al. Oral Candida colonization in patients with chronic periodontitis: Is there any relationship? Rev Iberoam Micol. 2018;35:134–9.
GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1211–59.
Jain M, Shah R, Chandolia B, et al. The oral carriage of Candida in oral cancer patients of Indian origin undergoing radiotherapy and/or chemotherapy. J Clin Diagn Res. 2016;10(2):17–20.
Javed F, Al-Kheraif A, Kellesarian S, Vohra F, Romanos G. Oral Candida carriage and species prevalence in denture stomatitis patients with and without diabetes. J Biol Regul Homeost Agents. 2017;31(2):343–6.
Jenkinson HF, Lamont RJ. Oral microbial communities in sickness and in health. Trends Microbiol. 2005;13(12):589–95.
Jewtuchowicz VM, Mujica MT, Malzone MC, Cuesta A, Brusca MI, Nastri ML, et al. Origin of the colonization of Candida dubliniensis in subgingival biofilm in immunocompetent subjects by RAPD-PCR assay. J Oral Microbiol. 2009;1(1):507.
Jewtuchowicz VM, Mujica MT, Brusca MI, Sordelli N, Malzone MC, Pola SJ, et al. Phenotypic and genotypic identification of Candida dubliniensis from subgingival sites in immunocompetent subjects in Argentina. Oral Microbiol Immunol. 2008;23(6):505–9.
Jewtuchowicz VM, Brusca MI, Mujica MT, Gliosca LA, Finquelievich JL, Iovannitti CA, Rosa AC. Subgingival distribution of yeast and their antifungal susceptibility in immunocompetent subjects with and without dental devices. Acta Odontol Latinoam. 2007;20:17–22.
Melton J, Redding S, Kirkpatrick W, et al. Recovery of Candida dubliniensis and other Candida species from the oral cavity of subjects with periodontitis who had poorly controlled type 2 diabetes: A pilot study. Spec Care Dentist. 2010;30(6):230–4.
Muthular M, Bálsamo F, Passero P, Jewtuchowicz V, Miozza V, Villalba MB, et al. Effects of tamoxifen on periodontal disease and Candida albicans of patients with breast cancer and other pathologies. Future Microbiol. 2019;14:129–37.
Newman MG, Takei HH, Klokkevold PR, Carranza FA. Newman and Carranza’s Clinical Periodontology. 13th ed. Philadelphia: Elsevier Health Sciences; 2019.
Mitova N, Rashkova M. Sex hormones in the saliva and periodontal health of children in puberty. J IMAB. 2019;25(4):2874–8.
Pazmiño VFC, Assem NZ, Pellizzer EP, De Almeida JM, Theodoro LH. Influencia del estrógeno en la enfermedad periodontal: Revisión de literatura. Av Periodon Implantol. 2015;27(2):75–8.
Preshaw P. Oral contraceptives and the periodontium. J Clin Periodontol 2000. 2013;61:125–59.
Rodríguez L, Rosa A, Rodríguez J, et al. The oral cavity: A reservoir that favors colonization and selection of Candida parapsilosis sensu stricto strains with high pathogen potential under conditions of gingival-periodontal disease. J Dent Sci Ther. 2017;2(1):1–6.
Rodríguez L, Jewtuchowicz V. Molecular characterization of Candida parapsilosis species complex in niches of the oral cavity in a cohort of patients from Argentina with different oral and dental clinical manifestations. J Dent Sci Ther. 2016;1(1):18–25.
Seneviratne CJ, Jin L, Samaranayake LP. Biofilm lifestyle of Candida: A mini review. Oral Dis. 2008;14(6):582–90.
Silk H. Diseases of the mouth. Prim Care. 2014;41(1):75–90.
Terças A, Marques S, Monteiro C, et al. Antifungal drug susceptibility of Candida species isolated from HIV-positive patients recruited at a public hospital in São Luis, Maranhão, Brazil. Front Microbiol. 2017;8:298.
Theill L, Dudiuk C, Morales-Lopez S, Berrio I, Rodríguez JY, Marin A, et al. Single-tube classical PCR for Candida auris and Candida haemulonii identification. Rev Iberoam Micol. 2018;35(2):110–2.
Truong T, Pang LM, Rajan S, Wong SSW, Fung YME, Samaranayake L, et al. The proteome of community living Candida albicans is differentially modulated by the morphologic and structural features of the bacterial cohabitants. Microorganisms. 2020;8(10):1541.
Yap M, Alnuaimi A, Adams G, McCullough M. Oral candidal carriage in asymptomatic patients. Aust Dent J. 2016;61(2):190–5.
Herrera D, Figuero E, Shapira L, Jin L, Sanz M. La nueva clasificación de enfermedades periodontales y periimplantarias. Rev Cient Soc Esp Periodoncia. 2018;11:1–8.
Looney WJ, Muhlemann K, Narita M. Stenotrophomonas maltophilia: An emerging opportunistic human pathogen. Lancet Infect Dis. 2009;9(5):312–23.
Jun L, Ying L, Yu Z, Changzheng W, Benyan W, Jun W. Actinomyces and alimentary tract diseases: A review of its biological functions and pathology. Biomed Res Int. 2018;2018:3820215.
Santarelli A, Mascitti M, Galeazzi R, Marziali A, Busco F, Procaccini M. Oral ulcer by Sphingomonas paucimobilis: First report. Int J Oral Maxillofac Surg. 2016;45(3):1–5.
Handschuh-Briones RA, Silva-Arcos EN, Urrutia M, Godoy-Martínez P. Actividad antifúngica de los enjuagues bucales frente a Candida albicans y Rhodotorula mucilaginosa: Un estudio in vitro. Rev Iberoam Micol. 2020;37(2):78–83.
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