Evaluation of the hepatoprotective effect of extracts of brown seaweed Sargassum ecuadoreanum
DOI:
https://doi.org/10.56294/hl2023249Keywords:
Polysaccharides, brown algae, hepatoprotective activity, liver diseases, CCl4 carbon tetrachlorideAbstract
This study consisted of evaluating the hepatoprotective effect present in the hydroalcoholic extract of brown algae (Sargassum ecuadoreanum) in mice. The collection was carried out on the beach Ballenita (Ecuador), chemical physical parameters were determined to the drug raw and the hydroalcoholic extract such as: Total ash, Water soluble ash, HCl insoluble ash, Total solids, Total fats, Humidity, Percentage of yield, total polysaccharides and sodium chloride. The induction was carried out with 5% intraperitoneally carbon tetrachloride and the treatment lasted for seven days. Seven groups were formed: a normal control group without treatment and without induction, an untreated negative control group, groups treated with Silymarin (420 mg/kg) and N-acetylcysteine (600 mg/kg orally) orally plus induction and groups treated with the hydroalcoholic extract of the research model at doses of 1000 mg/kg, 500 mg/kg, 250 mg/kg orally plus induction. A histopathological study and a biochemical assay were conducted to determine levels of Oxalactic Glutamic Transaminase (TGO). As a result, the sample presented total polysaccharides concentrations, the groups treated with Silymarin, N- acetyl cysteine and the hydroalcoholic extract at different doses, were similar to the transaminase values (TGO) of the normal control group, while the negative control group showed significant difference of 0.05%. Moreover, the histopathological study indicated that liver damage was in its first stage of injury, however, the hydroalcoholic extract of the brown seaweed Sargassum ecuadoreanum had a preventive hepatoprotective effect
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Copyright (c) 2023 Glenda Marcela Sarmiento Tomalá , Zoraida Burbano Gómez , Pilar Asunción Soledispa Cañarte , Alexandra López Barrera, Francisca Patricia Jimenez Granizo , María Guadalupe García Moncayo (Author)
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